The Chi lab investigates immunobiology, immunometabolism and cancer immunology, by focusing on metabolic regulation of the immune system and the therapeutic impacts on cancer and other diseases. As metabolic pathways are inextricably connected to immunity and cancer, understanding these connections allows us to gain new insights into biological concepts and disease targets. We are particularly interested in investigating the metabolic programs (e.g. amino acid and lipid metabolism), signaling pathways (e.g. mTOR and nutrient signaling), and systems-level regulatory networks that regulate basic T cell and dendritic cell biology and antitumor immunity. To this end, we apply interdisciplinary strategies by integrating immunological and genetic approaches with cutting-edge systems immunology and functional genomics tools, including in vivo CRISPR screening, single-cell transcriptomics, proteomics, metabolomics, and network reconstruction. Former trainees of the Chi lab have been principal investigators in multiple academic institutions. Please also see the following articles published over the past four years for additional information: Cell 187:205 (2024); Nature 624:154 (2023); Nature 620:200 (2023); Nature 623:1034 (2023); Nature Reviews Immunology 23:363 (2023); Nature 607:135 (2022); Nature 600:308 (2021); Nature 595:724 (2021); Nature 591:306 (2021); Cell 184:1245 (2021); and Nature Reviews Immunology 20:55 (2020);
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