Postdoctoral researcher position (M/F) - 3 years – NF-kappaB, Proteasome, Cancer and Immunology

Is the Job related to staff position within a Research Infrastructure? No

Offer Description

We are recruiting a postdoctoral researcher for a 3-year position to work on a project aimed at identifying new therapeutic strategies targeting the NF-κB pathway in two hematological malignancies: multiple myeloma and mantle cell lymphoma. This project is funded by the French National Cancer Institute (INCa).

Our recent work has led to the identification of new NF-κB regulators associated with the ubiquitin-proteasome system, as well as the characterization by mass spectrometry of the components of supramolecular complexes discovered in the laboratory that are involved in NF-κB activation. We have also demonstrated their constitutive presence in tumor cells. Compounds identified through a pharmacological screening approach represent promising therapeutic leads, including in models of bortezomib-resistant cell lines.

The project combines a fundamental research axis, aimed at gaining a better understanding of the molecular mechanisms involved in the regulation of the NF-κB signaling pathway induced by inflammatory cytokines, with an applied cancer research axis focused on identifying therapeutic targets in multiple myeloma and mantle cell lymphoma. The project may also extend to questions related to immunology, inflammation, and infection, taking advantage of the scientific environment of the CIMI and the laboratory's collaborations.

The postdoctoral researcher will investigate:

• the molecular mechanisms and new regulators controlling NF-κB activation in response to pro-inflammatory cytokines;
• the composition and dynamics of NF-κB activation complexes;
• the effects of the pharmacological targeting of regulators and proteins composing NF-κB-activating complexes in myeloma and lymphoma models, including bortezomib-sensitive and bortezomib-resistant models;
• the relevance of these findings in samples from patients with multiple myeloma.

The project benefits from a multidisciplinary research environment and collaborations with teams at the Institut Pasteur, the Toulouse Cancer Research Center (CRCT), and clinicians from AP-HP (Assistance Publique – Hôpitaux de Paris).

Keywords:
NF-κB – signaling – proteasome – ubiquitination – multiple myeloma – mantle cell lymphoma – cancer – immunology – inflammation – infection – streptococcus – CRISPR/Cas9 – proteomics – targeted therapy

Website of the "Cell Signaling and Pathogenesis" team: https://cimiparis.fr/equipes/robert-weil/

Where to apply

E-mail: emmanuel.laplantine@inserm.fr

Requirements

Research Field: Biological sciences » Biology

Education Level: PhD or equivalent

Skills/Qualifications

We are looking for a curious, rigorous and independent researcher, with a strong team spirit and the ability to develop scientific hypotheses.

The successful candidate will hold a PhD in cell and molecular biology, biochemistry, cancer biology, immunology, pharmacology, or a related field.

Experience in several of the following areas is desirable: cell culture, Western blotting, immunofluorescence/microscopy, CRISPR/Cas9 (KO/KI), protein–protein interactions, cell signaling, proteomics, flow cytometry, and cell-based pharmacology.

Specific Requirements

Experience in several of the following areas is desirable: cell culture, Western blotting, immunofluorescence/microscopy, CRISPR/Cas9 (KO/KI), protein–protein interactions, cell signaling, proteomics, flow cytometry, and cell-based pharmacology.

Languages: ENGLISH

Level: Good

Research Field: Biological sciences » Biology

Additional Information

Benefits

Salary: Starting from €2,997.20 gross per month, depending on professional experience, with the possibility of a higher salary based on professional experience in equivalent positions.

Monthly transport pass in Paris (75% paid by the institution)

Website for additional job details: https://cimiparis.fr/en/equipes/robert-weil-2/

Work Location(s)

Number of offers available: 1

Company/Institute: INSERM U1135

Country: France

City: PARIS

Postal Code: 75013

Street: 91 Boulevard de l'Hopital

Contact

City: Paris

Website: https://cimiparis.fr/en/

Street: 91 Boulevard de l'Hôpital

Postal Code: 75013