Traditionally, disease management involved the treatment of mastitis locally using antibiotic-loaded intramammary formulations, however there are issues with this approach, notably, poor retention within the udder, the development of antimicrobial resistance, the need to dispose of milk due to the presence of antibiotics and cost. Nowadays, the use of the local application of antibiotics has dramatically diminished and accordingly new prevention/treatment strategies are urgently required.
In conjunction with a veterinary company, we have developed a comprehensive understanding of the rheological properties required to ensure retention of gels within the udder. This PhD project will progress this understanding to develop novel intramammary formulations that provide controlled release of antimicrobial natural non-antibiotic, antimicrobial agents and prolonged retention within the udder.
Training that will be provided through the research project
Extensive training will be provided in a number of areas including, Pharmaceutical Rheology, Spectroscopy, Mechanical Analysis, Antimicrobial Testing.
Support will be given by a post-doctoral fellow
Expected impact activities
It is anticipated that this programme will result in a commercially available intramammary formulation
