Postdoc Positions

lack of knowledge on how EVs behave in biological environments and how their therapeutic cargo affects the metastasis targeting moieties present on their membranes. Seven believes that the lack of attention on the unknown biomolecular corona (BC) and on its role governing the EVs’ biological identity may well be behind such uncertainties. Understanding EVs’ BC formation will improve the rational EV-inspired nano-therapy design. SEVEN has been designed to generate substantial understating of the NPs-loaded therapeutic EVs behavior, the BC identity and its surface topography to generate new vectors with a much improved accumulation in metastasis target tissues. SEVEN will validate BC’s influence in the EVs metastasis targeting properties in a conceptually and operational ground-breaking experimental design to modify the BC’s surfactome composition for tailoring their therapeutic action.

Main tasks:

• Analysis of proteomics in NPs and EVs surface: mass spectrometry data generation and protein identification and quantification.
• Bioinformatics: differential expression analysis of molecules and modelling of the soft and hard components of the corona.
• Artificial intelligence application in NPs and EVs surfactome analysis.

Where to apply

Website: https://sede.unizar.es/?app=touz&opcion=mostrar&id=77907

Requirements

Research Field: Technology » Biotechnology

Education Level: PhD or equivalent

Research Field: Biological sciences » Biology

Education Level: PhD or equivalent

Research Field: Chemistry » Biochemistry

Education Level: PhD or equivalent

Skills/Qualifications

Qualifications/Skills

• PhD in Biotechnology, Bioinformatics, Nanotechnology.
• Expertise in proteomics, bioinformatic and artificial intelligence.
• Good English communication skills

Additional Information

Selection process

Scoring Criteria:

Section 1: Curriculum Vitae ................................................................................ up to 40 points

• Academic record.
• Research experience: Publications, patents, conference papers/communications, and stays abroad related to the activities to be carried out.
• Other valuable experience provided, other activities demonstrating initiative and leadership, languages, and IT/computer skills.

Section 2: ............................................................................................................ up to 50 points

• Experience related to bioinformatics (differential expression models), software proficiency, artificial intelligence, proteomic data processing, machine learning, deep learning, algorithms, statistical model application, and programming.
• Simulation models.

Section 3: ............................................................................................................ up to 10 points

• Laboratory experience with proteomic sample preparation, cell culture, and protein corona. Experience in nanomedicine.

In accordance with section 2.3 of the Equality Plan of the University of Zaragoza, approved by the Governing Council Agreement of February 23, 2016, a maximum of 1.5 points out of 100 will be added to the total score awarded in the evaluation of merits for candidates who have taken pregnancy-related leave or maternity/paternity leave in the three years prior to the call.

Interview: Option to conduct an interview, if agreed upon by the committee.

Work Location(s)

Number of offers available: 1

Company/Institute: Instituto Universitario de Investigación Mixto de Nanociencia y Materiales de Aragón, Instituto de Investigación Sanitaria de Aragón (IISA) y Hospital Miguel Servet Paseo Isabel la Católica, 1. Zaragoza.

Country: Spain

Contact

City: Zaragoza

Website: http://www.unizar.es

Street: c/ Pedro Cerbuna 12

Postal Code: 50009