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Position Function
Antimicrobial peptides are ubiquitous in animals and plants and are particularly abundant in barrier epithelia where they protect against opportunistic bacterial infection. AMPs are the major mechanism for antibacterial immune defense in adult D. melanogaster and other insects.
This project will examine the varied roles of distinct D. melanogaster AMPs in fighting a spectrum of bacterial infections, using evolutionary and functional genetic approaches in combination with cell biology and protein biochemistry.
We are particularly looking for scientists with expertise and/or interest in any of the following areas:
Genetics-based experiments to determine the roles of particular Drosophila AMPs in fighting distinct infections.
Protein biochemistry and manipulation to probe AMP function.
Microbiological assay of AMP effects on diverse bacteria, and bacterial responses to those AMPs.
Quantitative genetic analysis of AMP allelic variation in natural populations.
Molecular evolutionary and population genetic analysis of AMPs in D. melanogaster and across the genus Drosophila.
Anticipated Division of Time
85% – Conduct independent research, including design and execution of experiments, analysis of results, and preparation of findings for publication.
10% – Contribute to laboratory maintenance and community.
5% – Other, as needed.
Requirements
Required
Ph.D. in Biology, Genetics, Microbiology, or related field.
Minimum 4 years research experience in relevant discipline.
Preferred
Strong publication record demonstrating research independence and capacity to bring projects to completion.
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