R2B Senior Postdoctoral Researcher

Deadline: 23 Nov 2026 - 15:00 (Europe/Madrid) Country: Spain Type of Contract: Permanent Job Status: Full-time Is the job funded through the EU Research Framework Programme? Other EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description Call for applications for an R2B Senior Postdoctoral Researcher position to collaborate with the Oncogenesis and Antitumor Drugs Research Group (GOA) and the Pathophysiology of Lipid-Related Diseases Research Group (PLRD). Application deadline: 23 November 2026 at 3:00 p.m. About the Research Group We are seeking a highly motivated and talented postdoctoral researcher to build a bridge between two cutting-edge fields: protein-based nanocarrier engineering and in vivo preclinical cardiovascular validation. This interdisciplinary position is jointly promoted by the Oncogenesis and Antitumor Drugs Research Group (GOA), led by Dr. Ugutz Unzueta, and the Pathophysiology of Lipid-Related Diseases Research Group (PLRD), led by Dr. Noemí Rotllan, within the framework of the ambitious European project UNSOLVED-CARDS, funded by the Horizon Europe programme (Horizon-HLTH-2026-01-DISEASE-11). The project investigates shared and sex-specific mechanisms involved in cardiovascular diseases, including coronary artery disease, stroke, and abdominal aortic aneurysm, with the aim of developing targeted therapies and personalized risk prediction tools. Essential Requirements PhD degree in Biotechnology, Biochemistry, Biomedicine, or a related discipline. Accredited training for personnel responsible for the design and performance of procedures involving laboratory animals (Functions B/C or FELASA accreditation). Proven experience in protein engineering and nanotechnology and/or in murine models of cardiovascular diseases, particularly atherosclerosis, together with a strong motivation to work across both research fields. Oral and written proficiency in the two official languages of Catalonia. Candidates who do not meet this requirement must demonstrate adequate knowledge or commit to acquiring it within a maximum period of one year. Advanced level of English. Advanced proficiency in office software tools (Excel, Word, PowerPoint, etc.). The Following Will Be Valued Experience in molecular cloning, recombinant protein expression in E. coli , purification using techniques such as IMAC, IEX, and SEC, and biophysical characterization through SDS-PAGE, DLS, ESI, and related methodologies. Experience in protein conjugation with drugs or other cargo molecules and characterization of nanomaterials. Experience in cell culture and cell-based functional assays. Experience in flow cytometry and confocal microscopy will be considered an asset. Experience in in vivo animal handling, murine models of cardiovascular diseases, and in vivo imaging systems (IVIS). Experience in tissue processing, histology, immunohistochemistry (IHC), and immunofluorescence (IF). Strong skills in data management, analysis, and interpretation. Duties The successful candidate will work at the interface between nanomedicine and translational biology: Design and engineering of nanocarriers, including rational design, recombinant production, purification, and physicochemical characterization of protein nanoparticles specifically targeted to cells and prepared for conjugation. Cellular biodistribution studies, assessing the delivery and selectivity of targeted nanocarriers in major cardiovascular cell types through in vitro and ex vivo studies in vascular smooth muscle cells (VSMCs), endothelial cells (ECs), and macrophages. Translational validation of human multi-omics candidates, including methylation and proteomics data, in blood samples and atherosclerotic plaques from mouse models to guide therapeutic target selection. In vivo preclinical evaluation, including IVIS biodistribution imaging, pharmacokinetic profiling, safety assessment, and therapeutic efficacy studies of these nanoformulations in murine models of atherosclerosis. We Offer Permanent contract linked to the project: "Understanding Sex-Specific Omic Patterns Leading to Cardiovascular Disease Risk (UNSOLVED-CARDS)." Annual workload of 1,627.5 hours (37.5 hours per week). Salary according to the applicable collective agreement. Position jointly linked to the Oncogenesis and Antitumor Drugs Research Group (GOA) and the Pathophysiology of Lipid-Related Diseases Research Group (PLRD). Application Procedure and Deadline Interested candidates should preferably submit their documentation in PDF format by email to the Management of the Research Institute Foundation of Hospital de la Santa Creu i Sant Pau at seleccio@recercasantpau.cat, indicating reference 2026/153. Required documentation Cover letter. Updated Curriculum Vitae. Signed authorization for the processing of personal data. The deadline for submitting applications is 23 November 2026 at 3:00 p.m. Where to apply Website: https://recercasantpau.cat/en/w/2026_153-1-r2b-postdoc-s%C3%A9nior Requirements Research Field: Other Education Level: PhD or equivalent Work Location(s) Number of offers available: 1 Company/Institute: INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU Country: Spain Contact City: Barcelona Website: http://www.recercasantpau.cat Street: c/ Sant Quinti 77-79 Postal Code: 08041