Rate My Professor Marc-David Ruepp

Ruepp's laboratory employs advanced techniques including CRISPR, stem cell models, next-generation sequencing, and microscopy to study RNA-binding proteins like FUS and TDP-43, mitochondrial dysfunction, miRNA deregulation, nuclear pore interactions, and local mRNA translation in neurons. Key publications include “Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS” (Schweingruber et al., Nature Communications, 2025), “Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis” (Jutzi et al., Nature Communications, 2020), “Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants” (Reber et al., EMBO Journal, 2016), “Mutations in FUS lead to synaptic dysregulation in ALS-iPSC derived neurons” (Shum et al., Stem Cell Reports, 2024), and “A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons” (Hölbling et al., Cell Reports, 2025). He has obtained grants from the UK DRI and Motor Neurone Disease Association for research on ALS pathomechanisms, therapeutic RNA trans-splicing, and nuclear-synaptic signaling.