Rate My Professor Michael Cascio

Dr. Cascio’s research interests encompass membrane biophysics, signal transduction, lipids and bilayers, crosslinking mass spectrometry, and ion channels and transporters. His laboratory employs advanced biotechnological methods to produce and analyze brain receptors and channels, utilizing techniques such as circular dichroism spectroscopy, mass spectrometry, and chemical modifications to elucidate protein structures and functions. He investigates how lipid composition in cell membranes influences protein behavior. Notable publications include “Effects of membrane lipids on ion channel structure and function” (Tillman and Cascio, 2003, Cell Biochemistry and Biophysics), “Structure and function of the glycine receptor and related nicotinicoid receptors” (Cascio, 2004, Journal of Biological Chemistry), “Cross-Linking-Mass Spectrometry Studies of Cholesterol Interactions with Human α1 Glycine Receptor” (Ferraro and Cascio, 2018, Analytical Chemistry), and “Structural Studies of the Human α₁ Glycine Receptor via Site-Specific Chemical Cross-Linking Coupled with Mass Spectrometry” (Veeramachaneni et al., 2024, Biophysical Reports). Additionally, he co-holds U.S. Patent No. 8,957,036 for “Targeted Delivery of Glycine Receptors to Excitable Cells,” issued in 2015.