Rate My Professor Mohammad Nazim

The Nazim Lab defines the mechanistic interface between post-transcriptional RNA regulation and chromatin regulation that governs transcriptional and epigenetic programs in stem cell maintenance, cellular differentiation, tissue development, and disease. Research examines how alternative RNA splicing shapes these programs in embryonic stem cells and neuronal differentiation, the distinct functions of splice variants of chromatin regulators in lineage-specific differentiation, and how splicing defects contribute to neurodevelopmental disorders and cancer. The lab utilizes cell culture systems, genetically engineered mouse models, and genomic technologies. Nazim's publications include "Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of embryonic stem cell maintenance and neuronal differentiation" in Cell Stem Cell (2024), "Post-transcriptional regulation of the transcriptional apparatus in neuronal development" in Frontiers in Molecular Neuroscience (2024), "Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms" in Nucleic Acids Research (2017), and several on splicing regulation in congenital myasthenic syndromes.