Rate My Professor Ranjita Betarbet

Betarbet's research centers on the pathogenesis and pathology of neurodegenerative diseases, with a focus on interactions between Parkinson’s and Alzheimer’s disease-related genetic factors and external stressors, including mitochondrial impairment, oxidative stress, protein degradation, and protein trafficking pathways, and their roles in neurodegeneration. She has authored numerous publications in high-impact journals. Notable works include 'Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level' (Nature Neuroscience, 2022), 'Cell type-specific biotin labeling in vivo resolves regional neuronal and astrocyte proteomic differences in mouse brain' (Nature Communications, 2022), and 'Open drug discovery in Alzheimer’s disease' (Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2023). Recent contributions feature 'Integrated phenotypic and proteomic screening identifies top-tier Alzheimer’s disease therapeutic targets' and 'PAK1 inhibitor NVS-PAK1-1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice' (Alzheimer's & Dementia, 2025). Earlier influential papers include 'An In Vitro Model of Parkinson’s Disease' (Journal of Neuroscience, 2002). Her work advances understanding of proteomic changes and potential therapeutic targets in neurodegenerative disorders.