Rate My Professor Ronald Clarke

In 1999, Clarke joined the University of Sydney as Lecturer in Physical and Theoretical Chemistry, progressing to Senior Lecturer (2003-2012) and Associate Professor (2013-present). His research centers on the biophysical chemistry of membrane transport proteins, with a focus on P-type ATPases including Na+,K+-ATPase (cell volume control), H+,K+-ATPase (stomach acid production), and sarcoplasmic reticulum Ca2+-ATPase (muscle relaxation). He investigates lipid modulation of enzyme activity, electrostatic regulation by intrinsically disordered N-termini, and drug-membrane interactions using the SURFE²R platform, the only one in the Southern Hemisphere. Key publications encompass 'Cholesterol depletion inhibits Na+,K+-ATPase activity in a near-native membrane environment' (2019), 'Order-disorder transitions of cytoplasmic N-termini in the mechanisms of P-type ATPases' (2020), and a 2023 review on autoinhibitory regulation via electrostatic stabilization. With over 5,200 citations, his contributions have advanced insights into ion transport mechanisms and disease origins. Clarke served as Treasurer of the Australian Society for Biophysics (2013-2019), joined the Biophysical Reviews editorial board (2022), and has been Secretary-General of the International Union of Pure and Applied Biophysics (IUPAB) since 2022.